Physiology & Pharmacology
Sahar Heydari; Bahareh Amin; Akbar Pejhan; Seyed Jamal Mirmoosavi; Mohammad Mohammadzadeh
Volume 28, Issue 6 , January and February 2022, , Pages 911-922
Abstract
Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental syndrome with two main symptoms: repetitive behavior and social interaction disorder. Camel milk, due to its antioxidant, immune-modulating, anti-inflammatory, and anti-apoptotic properties maybe have beneficial effects on ASD.Materials ...
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Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental syndrome with two main symptoms: repetitive behavior and social interaction disorder. Camel milk, due to its antioxidant, immune-modulating, anti-inflammatory, and anti-apoptotic properties maybe have beneficial effects on ASD.Materials and Methods: Pregnant rats were injected intraperitoneally on day 12.5 of gestation with 500 mg/kg valproic acid. Then male neonatal rats were divided into five groups: Control group, valproic acid group, camel raw milk group + risperidone, and boiled camel milk group + risperidone. For the treatment period, rats have injected with risperidone (0.2 mg/kg) three times a week, and raw and boiled camel milk was given daily (10 ml/kg) for 42 days. Experiments of social interaction and repetitive behavior were measured at the beginning and end of the treatment period.Results: The offspring of mothers who received valproic acid had problems in social interactions, and sociability and social preference indexes were significantly reduced. Repetitive self-glooming behaviors also increased in VPA-rats. The treatment groups improved their social and repetitive behaviors after receiving camel milk and risperidone and were significantly different from the valproic acid and pre-treatment groups. Moreover, sociability and social preference indexes showed an increase after treatment with camel milk. Sociability index, social preference, social preference index, and repetitive behaviors before and after treatment between groups improved significantly (p <0.001) after treatment.Conclusion: Treatment with a camel milk diet improved the main behaviors of autism symptoms, such as social interactions and repetitive movements
Traditional medicine
bahareh amin; LEILA aldaghi; hamideh moalemzadeh; fatemeh soltani
Volume 28, Issue 2 , May and June 2021, , Pages 207-213
Abstract
Introduction: Breast cancer is the second common cancer in women at worldwide. Furthermore, patients with breast cancer generally use complementary and integrative medicine such as homeopathy. It has been shown that homeopathic remedies such as Sepia, Phosphorus and Pulsatilla have great effects ...
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Introduction: Breast cancer is the second common cancer in women at worldwide. Furthermore, patients with breast cancer generally use complementary and integrative medicine such as homeopathy. It has been shown that homeopathic remedies such as Sepia, Phosphorus and Pulsatilla have great effects in the various diseases such as some of the cancers. However, the cytotoxicity effects of these compounds have not been studied for breast cancer cell lines such asMCF-7. Hence, the aim of this study was to investigate the cytotoxic effects of these homeopathic remedies on breast cancer cell line. Materials & Methods: Breast cancer cells (MCF-7) were cultured in DMEM medium and treated with different potencies (30 and 200) of remedies for 24, 48 and 72 h. Cell viability was determined by MTT assay. Results: The findings indicate that none of the tested compounds had cytotoxicity effect on MCF-7 cancer cells. Conclusion: This study shows that Sepia, Phosphorus and Pulsatilla as the three of homeopathic remedies have not in vitro cytotoxic effects on breast cancer cell line, and it seems that further studies on different cell lines and also in vivo studies are needed to confirm these findings.
Physiology & Pharmacology
faranak jafari; omid gholami; Akbar Pejhan; bahareh amin; Samad Nazemi
Volume 25, Issue 4 , September and October 2018, , Pages 546-554
Abstract
Background and Purpose: Chronic neuropathic pain caused by damage or disturbance of the functioning of the somatosensory system are one of the major health problems and many people suffer from such diseases. The aim of this study was to investigate the effect of Umbelliprenin (UMB) on the symptoms of ...
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Background and Purpose: Chronic neuropathic pain caused by damage or disturbance of the functioning of the somatosensory system are one of the major health problems and many people suffer from such diseases. The aim of this study was to investigate the effect of Umbelliprenin (UMB) on the symptoms of neuropathic pain in chronic constriction injury model (CCI) of neuropathy in adult male rats.Materials and Methods: 24Wistar rats (250±20g) were randomly divided into 3 groups: sham, CCI and CCI+UMB (100μg/rat) groups. UMB was injected intrathecaly one day before surgery, and 3 days after surgery. Von Frey and Hot-Plate tests were performed one day before surgery and on days 2, 4, 7, 10 and 14 after surgery. The results were reported as mean and SEM (P